Title Suppression of Fas - mediated apoptosis via steric shielding by filovirus glycoproteins
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Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins.
Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expresse...
متن کاملDifferential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses.
The viral envelope glycoprotein (GP) is thought to play important roles in the pathogenesis of filovirus infection. It is known that GP expressed on the cell surface forms a steric shield over host proteins such as major histocompatibility complex class I and integrin β1, which may result in the disorder of cell-to-cell contacts and/or inhibition of the immune response. However, it is not clari...
متن کاملTitle Differential potential for envelope glycoprotein - mediated steric shielding of host cell surface proteinsamong
Title Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses Author(s) Noyori, Osamu; Matsuno, Keita; Kajihara, Masahiro; Nakayama, Eri; Igarashi, Manabu; Kuroda, Makoto; Isoda, Norikazu; Yoshida, Reiko; Takada, Ayato Citation Virology, 446(1-2): 152-161 Issue Date 2013-11 Doc URL http://hdl.handle.net/2115/54100 Type article (...
متن کاملSuppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells.
Stimulation of mature CD4 cells through the TCR induces cellular activation and expansion that are often followed by clonal elimination by a form of apoptosis termed activation-induced cell death. This process of CD4 cell apoptosis is generally thought to reflect clonal suicide and to be independent of other cell types. Here we show that during the response to the superantigen Staphylococcal en...
متن کاملPhosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).
Fas is constitutively expressed on endothelial cells, but in contrast to smooth muscle and other cell types, endothelial cells are highly resistant to Fas-mediated apoptosis. In this study, we examined the role of the serine/threonine kinase Akt/PKB in controlling the sensitivity of endothelial cells to Fas-mediated apoptosis. Serum deprivation inhibited expression of the caspase-8 inhibitor FL...
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تاریخ انتشار 2017